Lewisburg is a city in Marshall County, Tennessee, United States. The population was 10,413 at the 2000 census. It is the county seat of Marshall County. Lewisburg is located in central Tennessee, forty-eight miles south of Nashville and fifty-two miles north of Huntsville, Alabama along I-65. Located in the rolling hills of Middle Tennessee, Lewisburg took its name from the explorer Meriwether Lewis. By 1838, the town was supporting a newspaper and a bank. The downtown area is modeled after many small southern towns, with a courthouse in the center of the square surrounded by retail and commercial businesses. Shopping centers are located on the east and west ends of town.