Amissville is an unincorporated community in Rappahannock County in the U.S. state of Virginia. It is located on U.S. Route 211 about halfway between Warrenton and Washington. Amissville was first settled by French Huguenots and the English. In about 1763, Thomas Fairfax, 6th Lord Fairfax of Cameron granted tracts of land to Joseph Bayse and Joseph Amiss. Joseph Amiss distributed his land among his four sons, William, Gabriel, Philip, and Thomas. The Amissville post office was established on October 2, 1810, with Thomas Amiss acting as its first postmaster. The area was still largely inhabited by the Amiss and Bayse families, and both families wanted the town to be named in their own honor. An election was held, and by a one vote margin it became Amissville and not Bayseville. Famous locales include Bill Payne Auctions, Gray Ghost Vineyards and Santoonie.