Tallassee (first called Talisi by the Creek Indians) is a city on the Tallapoosa River, located in both Elmore and Tallapoosa counties in the U.S. state of Alabama. At the 2000 census the population was 4,934. It is home to a major hydroelectric power plant at Thurlow Dam operated by Alabama Power Company. The Elmore County portion of Tallassee is part of the Montgomery Metropolitan Statistical Area, while the Tallapoosa County portion is part of the Alexander City Micropolitan Statistical Area.