South Point is a village in Lawrence County, Ohio, United States, along the Ohio River. The population was 3,742 at the 2000 census. South Point is a part of the Huntington-Ashland, WV-KY-OH, Metropolitan Statistical Area (MSA). As of the 2000 census, the MSA had a population of 288,649. As of 2008, the mayor is William Gaskins.